Elevation of intrarenal adenosine by maleic acid decreases GFR and renin release
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Stimulation of renin release by intrarenal calcium infusion.
The effects of intrarenal infusions of calcium gluconate (10 and 100 micrograms Ca/kg/min) on renin secretion were studied in anesthetized mongrel dogs. In one group, the two doses of calcium were infused for 30 minutes each (1 ml/min). In a second group, the same doses were administered 30 minutes after the start of infusion of prostaglandin synthesis inhibitors (indomethacin 10 micrograms/kg/...
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Adenosine, at concentrations ranging from 5 to 100 microM, decreases the efficacy of transmission at the perforant path synapses on dentate granule cells. We have used whole cell recording from these cells in slices to determine the mechanism of the reduced synaptic strength. We find that size of miniature excitatory postsynaptic currents (mepscs) is unaffected by adenosine at concentrations up...
متن کاملDipyridamole decreases glomerular filtration in the sodium-depleted dog. Evidence for mediation by intrarenal adenosine.
To determine the renal effects of inhibiting the uptake and subsequent metabolism of endogenous adenosine, dipyridamole, a nucleoside transport inhibitor, was infused intrarenally into anesthetized dogs. Dipyridamole (24 micrograms/kg per min) inhibited the cellular extraction of [14C]adenosine (72 +/- 3% vs. 9 +/- 3%) and elevated the excretion of endogenous adenosine (0.60 +/- 0.08 to 1.70 +/...
متن کاملCellular and intrarenal control of renin secretion.
Tigerstedt and Bergman [l] showed, in 1898, that extracts of rabbit kidney cortex contained a vasopressor substance which they named renin. It was subsequently established that renin is an enzyme which acts upon a substrate of high MI, angiotensinogen, which is produced mainly by the liver. Renin catalyses the cleavage of the decapeptide angiotensin I (ANG I) from the substrate. The physiologic...
متن کاملInhibition of renin secretion by systemic and intrarenal angiotensin infusion.
BLAIR-WEST, J. R., J. I? COGHLAN, D. A. DENTON, J. W. FUNDER, B. A. SCOGGINS, AND R. D. WRIGHT. Inhibition of renin secretion by systemic and intrarenal angiotensin infusion. Am. J. Physiol. 220(5): 1309-1315. 197 1 .-Conscious sheep were allowed to become sodium depleted by loss of parotid saliva for 24 or 48 hr. Angiotensin II was infused continuously intravenously at 10, 20, or 60 pg/hr or i...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1986
ISSN: 0085-2538
DOI: 10.1038/ki.1986.236